STRUCTURAL AND FUNCTIONAL STUDIES OF FKHR-PAX3, A RECIPROCAL FUSION GENE OF THE T(2;13) CHROMOSOMAL TRANSLOCATION IN ALVEOLAR RHABDOMYOSARCOMA.

Structural and functional studies of FKHR-PAX3, a reciprocal fusion gene of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma.

Alveolar rhabdomyosarcoma (ARMS) is an aggressive pediatric cancer of skeletal muscle.More than 70% of ARMS tumors carry balanced t(2;13) chromosomal translocation that leads to the production of two novel fusion genes, PAX3-FKHR and FKHR-PAX3.While the PAX3-FKHR gene has been intensely studied, the reciprocal FKHR-PAX3 gene has rarely been describ

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